Fisetin Px (45 VegiCaps)

Key Ingredients: Fisetin Fisetin is present in low concentrations in many fruits and vegetables such as mangoes, apples, strawberries, kiwis, grapes, persimmon, onions, and smoke tree (Cotinus coggygria), the source for dietary supplements. Fisetin has been shown to affect multiple pathways involved in healthy aging and is reported to act as a neurotrophic, botanical antioxidant, and neuroprotective agent. Fisetin helps maintain healthy mitochondrial function in the presence of oxidative stress, preserves glutathione supply, and supports healthy cellular metabolism. It demonstrates a significant level of nerve and brain protection, boosting memory and new nerve cell growth. Fisetin is now in Phase II Clinical studies. Fenugreek (Trigonella foenum-graecum) Fenugreek contains galactomannans, compounds that boost the polyphenol fisetin’s bioavailability. Fenugreek has neuroprotective activity, positive effects on lipid and glucose metabolic function, as well as a modulatory effect on cognitive functions and mood states. Quercetin Quercetin, a flavonoid sourced from the plant Sophora japonica, has been researched for its modulating and regulatory action, supporting healthy inflammation and immunity along with mast cell stabilization. Black Pepper (Piper nigrum) Black pepper contains the active compound piperine, which enhances the bioavailability of many substances, including plant compounds.

Health Benefits: • Supports healthy senescence by clearing out “zombie cells” to better support longevity through optimal cell health and function. • Supports healthy neuronal cells, cognitive function, and mitochondrial function throughout ones senior years. • Safe, natural support for brain health and focus for seniors challenged with frailty, age-related decline of metabolic and neurological functions, and the aging immune system.

What is Fisetin? Fisetin is a bioactive flavonoid found in fruits and vegetables such as strawberry, apple, persimmon, grape, onion, and cucumber. Fisetin has been shown to affect multiple pathways involved in healthy aging and is reported to act as a neurotrophic, botanical antioxidant, and neuroprotective agent. Research shows it helps maintain healthy mitochondrial function in the presence of oxidative stress, increases GSH and acts to modulate inflammatory activity against microglial cells impacting age-related decline in brain function. Healthy Aging What is Senescence? Cell senescence is a natural process where a cell stops dividing due to various stressors such as aging, oxidation, or DNA damage, but it doesn’t die. This condition is often coined “zombie cell” because it continues to be metabolically active while releasing inflammatory chemicals (called SASP). SASP can spread and damage nearby healthy cells, thus contributing to aging and age-related diseases. Developing senolytic therapies that selectively target senescent cells may help delay the onset of aging signs and symptoms and improve resiliency and longevity. Cellular senescence can affect a person’s ability to recover from injuries, withstand stress or illness and learn new information. Senolytic treatment is often recommended as “hit and run” dosing, meaning high doses are used for a series of days each month, and then take a break for the remainder of the month. Fisetin is now in Phase II Clinical studies to better understand its senolytic properties.